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Gardel, Margaret
One or more keywords matched the following properties of Gardel, Margaret
PropertyValue
keywords Adhesion, Cell
overview My lab is dedicated to understanding how cell adhesion and migration is regulated by the physical behaviors and structure of the actin cytoskeleton, focal adhesions and cell-cell adhesions and how the physical behaviors of complex cytoskeletal machines emerge from their molecular constituents. We employ approaches from condensed matter physics, cell biology and biochemistry to study the physical properties of the actin cytoskeleton and focal adhesions within live cells and in reconstituted systems of purified proteins.
One or more keywords matched the following items that are connected to Gardel, Margaret
Item TypeName
Concept Cell Adhesion
Concept Cell Adhesion Molecules
Academic Article Myosin II-mediated focal adhesion maturation is tension insensitive.
Academic Article Model for adhesion clutch explains biphasic relationship between actin flow and traction at the cell leading edge.
Academic Article Dynamic and structural signatures of lamellar actomyosin force generation.
Academic Article Regulation of cell motile behavior by crosstalk between cadherin- and integrin-mediated adhesions.
Academic Article Optimization of traction force microscopy for micron-sized focal adhesions.
Academic Article Mechanical integration of actin and adhesion dynamics in cell migration.
Academic Article Biophysics. Clutch dynamics.
Academic Article Probing intracellular force distributions by high-resolution live cell imaging and inverse dynamics.
Academic Article Contact guidance requires spatial control of leading-edge protrusion.
Academic Article Lamellipodium is a myosin-independent mechanosensor.
Academic Article Dia1-dependent adhesions are required by epithelial tissues to initiate invasion.
Academic Article Geometry regulates traction stresses in adherent cells.
Academic Article Stressing the limits of focal adhesion mechanosensitivity.
Academic Article Cell-ECM traction force modulates endogenous tension at cell-cell contacts.
Academic Article Preparation of complaint matrices for quantifying cellular contraction.
Academic Article Protrusive activity guides changes in cell-cell tension during epithelial cell scattering.
Academic Article F-actin buckling coordinates contractility and severing in a biomimetic actomyosin cortex.
Academic Article Cell-substrate interactions.
Academic Article A zyxin-mediated mechanism for actin stress fiber maintenance and repair.
Academic Article Conserved F-actin dynamics and force transmission at cell adhesions.
Academic Article Force localization modes in dynamic epithelial colonies.
Academic Article Dia1 coordinates differentiation and cell sorting in a stratified epithelium.
Academic Article Force-dependent intercellular adhesion strengthening underlies asymmetric adherens junction contraction.
Grant Mechanical Regulation of Cell Adhesion by Dynamic Cytoskeletal Assemblies
Grant 2007 NIH Director's Pioneer Award Program (DP1)
Academic Article Machine learning interpretable models of cell mechanics from protein images.
Search Criteria
  • Adhesion Cell